Gut & Digestive Health
I've eliminated gluten, dairy, and half my diet.
I still feel terrible after meals.
Something is wrong that diet changes aren't reaching.
Gut dysfunction is rarely just about digestion. A disrupted microbiome drives systemic inflammation, weakens immune function, disrupts neurotransmitter production, and contributes to conditions throughout the body — including many that don’t seem digestive at all. Brain fog, skin issues, fatigue, joint pain, and mood disorders can all trace upstream to the gut.
At One Tree we use microbiome mapping, food intolerance panels, intestinal permeability testing, and a complete picture of your digestive environment to find what ‘eat better’ advice couldn’t reach. This is a systematic investigation — not a dietary overhaul conversation.
On this page
Why gut health affects the whole body
What conventional GI testing misses
How One Tree investigates it
Treatments we use
Conditions in this category
“I’ve been tested for everything. Colonoscopy, endoscopy, breath tests. Everything came back fine. But I felt terrible every single day.“
Why the Gut Matters
More than digestion.
The gut does far more than process food. It houses roughly 70% of the immune system. It produces a significant portion of the body’s serotonin and other neurotransmitters. It regulates systemic inflammation. When the gut is dysregulated, the effects show up everywhere — and often in places that look completely unrelated to digestion.
This is why patients with IBS, SIBO, leaky gut, or chronic food reactions often present with brain fog, anxiety, fatigue, skin conditions, joint pain, or immune dysfunction alongside — or even instead of — obvious GI symptoms. The gut connection is real, well-documented, and consistently underinvestigated in standard care.
Dietary changes help some people. They don’t reach everyone — particularly when the underlying microbiome disruption, permeability issue, or infection hasn’t been identified and addressed directly.
What Standard Testing Misses
Why a normal colonoscopy isn't a full answer.
Conventional GI workups are designed to rule out structural disease — polyps, inflammation, obvious infection. They do that well. What they don’t assess:
Microbiome composition — Standard stool cultures identify a narrow range of pathogens. Comprehensive microbiome mapping reveals the full bacterial, fungal, and parasitic environment — including imbalances that drive chronic symptoms without being technically ‘pathological’.
Intestinal permeability — ‘Leaky gut’ — compromised gut barrier integrity — isn’t assessed by colonoscopy. It requires specific functional testing and is a primary driver of systemic inflammation and immune activation.
Food sensitivities vs. allergies — Standard allergy panels test IgE reactions. The more common IgG and IgA food sensitivities — which cause delayed, diffuse symptoms rather than acute reactions — require different panels.
SIBO — Small intestinal bacterial overgrowth is a common and frequently missed cause of bloating, gas, and bowel irregularity that requires specific breath testing to diagnose.
Our Approach
A systematic investigation of your digestive environment.
The investigation starts with your full GI history — symptoms, timeline, what you’ve already eliminated from your diet, what testing has been done, and what it showed. From there, we use targeted functional testing to build a clear picture of what’s actually happening in your digestive environment.
We also look upstream. Because gut dysfunction doesn’t occur in isolation — stress, hormones, sleep, and prior antibiotic or medication use all affect the microbiome. Understanding the full picture is what makes the treatment plan hold.
What We Investigate
Comprehensive microbiome mapping (bacteria, fungi, parasites) · Intestinal permeability (leaky gut) testing · SIBO breath testing · Food intolerance and sensitivity panels (IgG & IgA) · Digestive enzyme function · Gut-brain axis and neurological contributions · Inflammatory markers driven by gut dysfunction · Hormonal and stress contributions to gut health
Conditions in this category
IBS (Irritable Bowel Syndrome)
IBD (Crohn’s & Ulcerative Colitis) — supportive care
SIBO (Small Intestinal Bacterial Overgrowth)
Food sensitivities & intolerances
Bloating, gas & chronic discomfort
Leaky gut & intestinal permeability
Gut-driven brain fog
Chronic nausea
Gut-related skin conditions
Gut-related mood & anxiety
How We Treat It
Treatments we use for gut & digestive conditions.
What’s used depends on what the investigation finds. Most gut protocols at One Tree combine two or more of these, because the contributing factors typically interact.
Microbiome Restoration
Targeted probiotic, prebiotic, and antimicrobial protocols based on what the microbiome mapping actually shows — not a generic probiotic recommendation. Addresses bacterial overgrowth, dysbiosis, fungal imbalance, and parasitic contributors specific to your profile.
Gut Permeability Repair
When intestinal permeability testing confirms a compromised gut barrier, a targeted repair protocol addresses the lining directly — using specific nutrients, peptides (BPC-157 in particular), and dietary modifications that support structural repair rather than just symptom management.
Food Sensitivity Elimination & Reintroduction
Based on IgG and IgA panel results — not guesswork or generic elimination diets. We identify the specific foods driving your immune response, remove them systematically, monitor the response, and guide a structured reintroduction once gut repair is underway.
Peptide Therapy
BPC-157 (Body Protection Compound) has a strong clinical record for gut healing — supporting mucosal repair, reducing gut inflammation, and accelerating recovery from conditions ranging from leaky gut to IBD. Used alongside other gut protocols when the case warrants it.
What to Expect
From investigation to a protocol that holds.
Most patients who arrive at One Tree with gut issues have already modified their diet significantly and seen at least one GI specialist. We start from what’s already been done — what helped, what didn’t, and what hasn’t been tested.
Free 40-Min Consultation
A conversation about your digestive history, what testing has been done, what you’ve already eliminated, and whether One Tree’s approach is likely to add something your prior workups didn’t.
Deep-Dive Intake (60+ min)
Full GI history, diet history, medication and supplement history, stress and sleep patterns, and any symptoms that seem unrelated to digestion — these often turn out to be connected.
Functional Testing
Microbiome mapping, permeability testing, SIBO breath test, food sensitivity panels — chosen based on your specific history and what standard testing hasn’t covered.
Your Protocol
A targeted plan based on findings — not a generic gut-health program. Most protocols run 3–6 months, with check-ins to assess response and adjust as needed.
Honest expectations
Gut restoration takes time. Microbiome changes and intestinal permeability repair typically require 3–6 months of consistent protocol before the full picture is clear.
Diet changes will likely be part of the protocol. The difference here is that they’ll be based on your specific test results — not a general elimination approach.
If your GI symptoms point to something requiring specialist management — IBD requiring biologics, for example — Dr. Jamie will identify that and coordinate accordingly.
Bring a record of what you’ve already eliminated and any prior GI testing. Knowing what’s been ruled out is as useful as knowing what hasn’t been tested.
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“I had IBS for eight years. Two gastroenterologists, multiple elimination diets, a FODMAP protocol that helped a little but never resolved it. Dr. Jamie found SIBO and a severe microbiome imbalance that had never been tested for. Six months later I eat normally for the first time since college.”
One Tree Patient · Colorado · IBS & SIBO
*Patient experience. Results vary. This is not a medical claim.
If you've been told your gut tests are normal
but nothing has resolved — that's where we start.
The free consultation is a 40-minute conversation about your history and whether One Tree’s approach makes sense for your situation. No forms, no commitment beforehand.